The Bighorn Medicine Wheel is a stone circle roughly 80 feet in diameter with 28 spokes radiating from a central cairn, situated on an exposed ridge at 9,642 feet elevation in the Bighorn Mountains. It is sacred to multiple Plains nations — Crow, Cheyenne, Lakota, Arapaho, Shoshone, and others — each of whom has distinct traditions regarding its origin and purpose.

Crow oral tradition attributes the wheel's construction to the culture hero Red Plume. Cheyenne tradition connects it to the prophet Sweet Medicine. For many Plains peoples, the site is a place of vision questing, prayer, and offering — the high elevation and exposed location making it a place where the sky world feels close. Offerings of tobacco, cloth, and sage are left at the cairns.

The 28 spokes have been interpreted as corresponding to the 28 days of the lunar cycle, connecting the wheel to Plains traditions of astronomical observation and ceremonial calendars. The site's power is understood as deriving from its position — high, exposed, at the boundary between earth and sky, visible for miles across the surrounding ridges and valleys.